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Chirayu Patel, Leif Stenke, Sudhir Varma, Marita Lagergren Lindberg, Magnus Björkholm, Jan Sjöberg, Kristina Viktorsson, Rolf Lewensohn, Ola Landgren, Michael M. Gottesman and Jean-Pierre Gillet Multidrug resistance in relapsed acute myeloid leukemia: Evidence of biological heterogeneity Cancer 119

Article first published online: 14 MAY 2013 | DOI: 10.1002/cncr.28098

Analysis of paired samples taken at diagnosis and after relapse from a group of leukemia patients with drug-resistant cancer revealed that each patient had a unique gene signature representing different mechanisms of resistance. The data underline the need for personalized molecular analysis in order to design specific treatments suitable for individual patients with acute myeloid leukemia.

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