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Edmund A. Mroz, Aaron D. Tward, Curtis R. Pickering, Jeffrey N. Myers, Robert L. Ferris and James W. Rocco High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma Cancer 119

Version of Record online: 20 MAY 2013 | DOI: 10.1002/cncr.28150

Higher intratumor genetic heterogeneity was associated with shorter overall survival among patients with head and neck squamous cell carcinoma, particularly for those receiving chemotherapy. The quantitative measure of heterogeneity used in the current study, based on next-generation genomic DNA sequencing, can be evaluated similarly in other combinations of cancers and therapies to test the long-standing hypothesis that highly heterogeneous tumors contribute to poor patient outcomes.

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