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Marilyn Huang, Bojana Djordjevic, Melinda S. Yates, Diana Urbauer, Charlotte Sun, Jennifer Burzawa, Molly Daniels, Shannon N. Westin, Russell Broaddus and Karen Lu Molecular pathogenesis of endometrial cancers in patients with Lynch syndrome Cancer 119

Article first published online: 12 JUN 2013 | DOI: 10.1002/cncr.28152

Hyperplasia is part of the preinvasive spectrum of disease in Lynch syndrome (LS)-associated endometrial cancer (EC), as indicated by the presence of concurrent complex hyperplasia and complex atypical hyperplasia in cases of LS-associated EC cases. Although loss of phosphatase and tensin homolog is common in both LS and sporadic EC cases, there was a lack of additional mutations noted in LS-associated EC, suggesting that within the context of the mismatch repair defects in LS, fewer additional molecular changes are required to progress from preinvasive lesions to carcinoma.

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