Andreas A. Argyriou, Guido Cavaletti, Anna Antonacopoulou, Armando A. Genazzani, Chiara Briani, Jordi Bruna, Salvatore Terrazzino, Roser Velasco, Paola Alberti, Marta Campagnolo, Sara Lonardi, Diego Cortinovis, Marina Cazzaniga, Cristina Santos, Aikaterini Psaromyalou, Aikaterini Angelopoulou and Haralabos P. Kalofonos Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: Results from a prospective multicenter study Cancer 119
Article first published online: 2 JUL 2013 | DOI: 10.1002/cncr.28234
To the authors' knowledge, no reliable genetic or molecular biomarkers have been identified to date to detect patients at high risk of developing oxaliplatin-induced peripheral neuropathy (OXAIPN). The results of the current study provide evidence to support a causal relationship between voltage-gated sodium channel (SCNA) polymorphisms and OXAIPN.
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