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Larry L. Wang, Rie Suganuma, Naohiko Ikegaki, Xao Tang, Arlene Naranjo, Patrick McGrady, Wendy B. London, Michael D. Hogarty, Julie M. Gastier-Foster, A. Thomas Look, Julie R. Park, John M. Maris, Susan L. Cohn, Robert C. Seeger and Hiroyuki Shimada Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: A report from the Children's Oncology Group Cancer 119

Version of Record online: 30 JUL 2013 | DOI: 10.1002/cncr.28251

Neuroblastoma, undifferentiated subtype, which is the histologically defined entity composed of neuroblasts often having prominent nucleoli, is frequently associated with poor prognostic factors. In this subtype, MYC protein expression could indicate more aggressive clinical behavior than MYCN amplification and subsequent MYCN protein expression.

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