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Steven E. Lipshultz, Stuart R. Lipsitz, Jeffery L. Kutok, Tracie L. Miller, Steven D. Colan, Donna S. Neuberg, Kristen E. Stevenson, Mark D. Fleming, Stephen E. Sallan, Vivian I. Franco, Jacqueline M. Henkel, Barbara L. Asselin, Uma H. Athale, Luis A. Clavell, Bruno Michon, Caroline Laverdiere, Eric Larsen, Kara M. Kelly and Lewis B. Silverman Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia Cancer 119

Version of Record online: 16 JUL 2013 | DOI: 10.1002/cncr.28256

Doxorubicin is associated with progressive cardiac dysfunction, possibly by forming doxorubicin-iron complexes leading to free-radical injury. In the current study, doxorubicin-associated myocardial injury was associated with carriers of the C282Y allele, a common allelic variant of hemochromatosis, among long-term survivors of childhood high-risk acute lymphoblastic leukemia.

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