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Zhe Jin, Zhenfu Zhao, Yulan Cheng, Ming Dong, Xiaojing Zhang, Liang Wang, Xinmin Fan, Xianling Feng, Yuriko Mori and Stephen J. Meltzer Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer Cancer 119

Article first published online: 24 JUL 2013 | DOI: 10.1002/cncr.28276

Using real-time, quantitative, methylation-specific polymerase chain reaction, the authors examined promoter hypermethylation of endoglin (ENG) in 260 endoscopic esophageal biopsy specimens of differing histologies. Results demonstrated that hypermethylation of ENG is a common, tissue-specific event in patients with esophageal squamous cell carcinoma and exhibits a field defect in normal mucosa with potential biomarker implications for the early detection of this disease.

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