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Mehrnaz Fatemi, Thomas A. Paul, Garrett M. Brodeur, Babak Shokrani, Hassan Brim and Hassan Ashktorab Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages Cancer 120

Version of Record online: 14 NOV 2013 | DOI: 10.1002/cncr.28316

Colorectal cancer develops through an adenoma-adenocarcinoma carcinogenesis process, and this sequential process is driven by 3 molecular pathways: chromosomal instability, microsatellite instability, and CpG island methylation. This study was conducted to explore whether the CHD5 gene acts as a tumor-suppressor or oncogene in colon cancer.

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