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Yun Chen, Meiling Zhu, Zhen Zhang, Guoliang Jiang, Xiaolong Fu, Min Fan, Menghong Sun, Qingyi Wei and Kuaile Zhao A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy Cancer 119

Version of Record online: 10 SEP 2013 | DOI: 10.1002/cncr.28338

Six potentially functional single nucleotide polymorphisms are genotyped in 3 base-excision repair genes, FEN1, hOGG1, and NEIL1, from 187 patients with esophageal squamous cell carcinoma who received definitive radiotherapy with or without chemotherapy. The results indicate that the NEIL1 rs4462560 polymorphism may serve as a reliable predictor of acute radiation-induced esophageal toxicity and radiation pneumonitis risk.

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