Akito Hata, Nobuyuki Katakami, Hiroshige Yoshioka, Jumpei Takeshita, Kosuke Tanaka, Shigeki Nanjo, Shiro Fujita, Reiko Kaji, Yukihiro Imai, Kazuya Monden, Takeshi Matsumoto, Kazuma Nagata, Kyoko Otsuka, Ryo Tachikawa, Keisuke Tomii, Kei Kunimasa, Masahiro Iwasaku, Akihiro Nishiyama, Tadashi Ishida and Yoshihiro Nishimura Rebiopsy of non–small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor Cancer 119
Article first published online: 16 SEP 2013 | DOI: 10.1002/cncr.28364
Rebiopsy to confirm T790M status can be challenging due to limited tissue availability and procedural feasibility, and little is known regarding the differences among patients with or without T790M. Results of this study demonstrated low prevalence of T790M in central nervous system and prognostic impact of T790M after acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor.
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