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Matthew E. Nielsen, Angela B. Smith, Anne-Marie Meyer, Tzy-Mey Kuo, Seth Tyree, William Y. Kim, Matthew I. Milowsky, Raj S. Pruthi and Robert C. Millikan Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States: 1988 to 2006 Cancer 120

Article first published online: 10 OCT 2013 | DOI: 10.1002/cncr.28397

The authors observed what to their knowledge is a previously unappreciated increase in adjusted incidence rates of low-risk, papillary noninvasive (Ta) bladder cancer, the overwhelming majority of which was low grade, in the United States from 1988 through 2006. The trend appears to be driven in large part by dramatic increases in the incidence of Ta disease among the oldest age strata, suggesting a cohort phenomenon warranting further investigation given the differential molecular biology of low-grade versus high-grade urothelial carcinoma.

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