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Evelyn M. Brosnan, Andrew J. Weickhardt, Xian Lu, Delee A. Maxon, Anna E. Barón, Michel Chonchol and D. Ross Camidge Drug-induced reduction in estimated glomerular filtration rate in patients with ALK-positive non-small cell lung cancer treated with the ALK inhibitor crizotinib Cancer 120

Article first published online: 20 NOV 2013 | DOI: 10.1002/cncr.28478

The creatinine-based estimated glomerular filtration rate (eGFR) is reduced by treatment with crizotinib, but the majority of patients will recover their eGFR after the cessation of therapy. Because the etiology is unclear, increased vigilance with regard to the concomitant use of renally cleared medications or nephrotoxic agents should be considered for patients receiving crizotinib and, when the eGFR is reduced, additional renal investigations should be undertaken.

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