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Mohamad Mohty, Florent Malard, Bilal Mohty, Bipin Savani, Philippe Moreau and Evangelos Terpos The effects of bortezomib on bone disease in patients with multiple myeloma Cancer 120

Article first published online: 18 NOV 2013 | DOI: 10.1002/cncr.28481

Beyond antimyeloma activity, bortezomib demonstrates significant effects on bone metabolism. Preclinical and clinical data have suggested that bortezomib directly stimulates osteoblast growth and differentiation while also inhibiting osteoclast development and activity.

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