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Roberto Agresti, Gabriele Martelli, Marco Sandri, Elda Tagliabue, Maria Luisa Carcangiu, Ilaria Maugeri, Cristina Pellitteri, Cristina Ferraris, Giuseppe Capri, Angela Moliterni, Giulia Bianchi, Gabriella Mariani, Giovanna Trecate, Laura Lozza, Martin Langer, Mario Rampa, Massimiliano Gennaro, Marco Greco, Sylvie Menard and Marco A. Pierotti Axillary lymph node dissection versus no dissection in patients with T1N0 breast cancer: A randomized clinical trial (INT09/98) Cancer 120

Article first published online: 5 DEC 2013 | DOI: 10.1002/cncr.28499

A 10-year outcome study was performed in 517 women (mean age, 52.6 years [range, 30 years-65 years]) with T1N0 breast cancer who were treated with conservative surgery and prospectively randomized to either axillary lymph node dissection or observation. Adjuvant treatment was based on biological factors of the primary tumor in the group of patients who received no axillary surgery. Overall survival and disease-free survival did not appear to differ significantly between treatment arms, thereby indicating that axillary surgery may be avoided in these patients.

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