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Florence K. Keane, Ming-Hui Chen, Danjie Zhang, Marian J. Loffredo, Philip W. Kantoff, Andrew A. Renshaw and Anthony V. D'Amico The likelihood of death from prostate cancer in men with favorable or unfavorable intermediate-risk disease Cancer 120

Version of Record online: 6 MAR 2014 | DOI: 10.1002/cncr.28609

The lack of prostate cancer (PC) deaths among men with favorable intermediate-risk PC suggests that adding androgen-suppression therapy may not reduce their risk of PC-specific mortality; whereas many men with unfavorable intermediate-risk PC are at increased risk for harboring occult PC with Gleason scores from 8 to 10 and may benefit from long-term androgen-suppression therapy. Multiparametric magnetic resonance imaging and targeted biopsy of suspicious lesions should be considered to identify occult PC with Gleason scores from 8 to 10 in these men.

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