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Alec E. Vaezi, Gerold Bepler, Nikhil R. Bhagwat, Agnes Malysa, Jennifer M. Rubatt, Wei Chen, Brian L. Hood, Thomas P. Conrads, Lin Wang, Carolyn E. Kemp and Laura J. Niedernhofer Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas Cancer 120

Version of Record online: 1 APR 2014 | DOI: 10.1002/cncr.28643

The monoclonal antibody 8F1 has been used to determine ERCC1 levels to predict platinum efficacy and as a prognostic marker for the survival of patients with malignancies. The results of the current study demonstrate that 8F1 detects 2 unrelated proteins, ERCC1 and choline phosphate cytidylyltransferase-α (CCTα), and that CCTα is prognostic for survival in patients with lung and head and neck squamous cell carcinomas.

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