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Shuang Qu, Bin Liu, Xiaoling Guo, Hongshun Shi, Meifeng Zhou, Li Li, Shulan Yang, Xiuzhen Tong and Haihe Wang Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia Cancer 120

Version of Record online: 15 APR 2014 | DOI: 10.1002/cncr.28668

FLT3-ITD–negative acute myeloid leukemia (AML) accounts for up to approximately 70% to 80% of all cases. This study demonstrates that PRL-3, an independent driver in FLT3-ITD–negative AML, is adversely correlated to patient survival. Mechanistically, PRL-3 can promote AML cell cycle progression and render antiapoptosis features to AML cells, suggesting it could be an independent factor for AML diagnosis and therapy.

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