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Youngjoo Lee, Geon Kook Lee, Yeon-Su Lee, Wenji Zhang, Jung-Ah Hwang, Byung-Ho Nam, Seok Hyun Kim, Joo-Hang Kim, Tak Yun, Ji-Youn Han, Heung Tae Kim and Jin Soo Lee Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations Cancer 120

Article first published online: 15 APR 2014 | DOI: 10.1002/cncr.28711

The presence of a preexisting T790M mutation is not a rare event in patients with epidermal growth factor receptor-mutant lung cancer and the frequency of the T790M mutation within a tumor has a critical impact on the tumor's biological characteristics and the clinical outcomes of therapy with epidermal growth factor receptor tyrosine kinase inhibitors.

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