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Adrian G. Sacher, Pasi A. Jänne and Geoffrey R. Oxnard Management of acquired resistance to epidermal growth factor receptor kinase inhibitors in patients with advanced non-small cell lung cancer Cancer 120

Article first published online: 17 APR 2014 | DOI: 10.1002/cncr.28723

The widespread adoption of epidermal growth factor receptor (EGFR) kinase inhibitors for the first-line treatment of patients with advanced EGFR-mutated non-small cell lung cancer has resulted in kinase inhibitor resistance becoming a ubiquitous clinical problem. In this article, the authors review the mechanisms, clinical management, and emerging therapies for acquired resistance in patients with EGFR-mutated non-small cell lung cancer.

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