E-mail a Wiley Online Library Link

Rona Yaeger, Andrea Cercek, Joanne F. Chou, Brooke E. Sylvester, Nancy E. Kemeny, Jaclyn F. Hechtman, Marc Ladanyi, Neal Rosen, Martin R. Weiser, Marinela Capanu, David B. Solit, Michael I. D'Angelica, Efsevia Vakiani and Leonard B. Saltz BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer Cancer 120

Version of Record online: 15 APR 2014 | DOI: 10.1002/cncr.28729

In this analysis of what to the authors' knowledge is the largest series of BRAF-mutant metastatic colorectal cancer cases published to date, it was found that BRAF-mutant metastatic colorectal tumors are infrequently associated with PIK3CA co-mutation, commonly spread to the peritoneum, less frequently present with disease limited to the liver, and exhibit a shorter survival duration after complete resection of metastatic disease. The data from the current study suggest that BRAF mutation testing has prognostic value in patients with metastatic colorectal cancer, including those undergoing complete resection for curative intent.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field