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Peter Birner, Stefan Pusch, Christo Christov, Stiliana Mihaylova, Kalina Toumangelova-Uzeir, Sevdalin Natchev, Sebastian F. Schoppmann, Andrey Tchorbanov, Berthold Streubel, Jochen Tuettenberg and Marin Guentchev Mutant IDH1 inhibits PI3K/Akt signaling in human glioma Cancer 120

Article first published online: 25 APR 2014 | DOI: 10.1002/cncr.28732

Isocitrate dehydrogenase 1 (IDH1) is a major player in glioma pathogenesis with an unknown signaling pathway allocation. This study provides several lines of evidence that mutant IDH1 influences PI3K (phosphoinositol 3-kinase)/Akt signaling.

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