Stewart M. Knoepp, Diane L. Kuebler and David C. Wilbur Correlation between hybrid capture II high-risk human papillomavirus DNA test chemiluminescence intensity from cervical samples with follow-up histologic results Cancer Cytopathology 118
Results of high-risk human papillomavirus (hrHPV) testing obtained by the Hybrid Capture II test falling in the “equivocal” range are associated with a significant degree of high-grade cervical intraepithelial neoplasia (CIN). Therefore, these tests should be managed as being unequivocally positive for hrHPV. The chemiluminescence intensity of an unequivocal positive Hybrid Capture II hrHPV test does not appear to independently predict the rate of associated high-grade CIN.
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