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N. Paul Ohori, Rashi Singhal, Marina N. Nikiforova, Linwah Yip, Karen E. Schoedel, Christopher Coyne, Kelly L. McCoy, Shane O. LeBeau, Steven P. Hodak, Sally E. Carty and Yuri E. Nikiforov BRAF mutation detection in indeterminate thyroid cytology specimens Cancer Cytopathology 121

Version of Record online: 7 AUG 2012 | DOI: 10.1002/cncy.21229

The BRAF mutation is found not only in malignant cytology cases but also in indeterminate thyroid cases. For these indeterminate cases with a BRAF mutation, the authors find that the specific cytology diagnoses (atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, and suspicious for malignancy) reflect differences in the nature of cytology specimens, molecular characteristics, and histologic subtypes of papillary thyroid carcinoma.

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