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Renu Khode, Douglas A. Larsen, Brianne C. Culbreath, Shane Parrish, Kimberly L. Walker, Lubna Sayage-Rabie, Robert S. Beissner and Arundhati Rao Comparative study of epidermal growth factor receptor mutation analysis on cytology smears and surgical pathology specimens from primary and metastatic lung carcinomas Cancer Cytopathology 121

Version of Record online: 30 JAN 2013 | DOI: 10.1002/cncy.21273

Epidermal growth factor receptor (EGFR) mutation status, which is used to qualify patients with non–small cell lung cancer for tyrosine kinase inhibitor therapy, depends on assay and platform selection as well as specimen type. Cytology smears can be used successfully as a specimen source for EGFR gene mutation analysis and can produce results comparable to those achieved with surgical specimens on both polymerase chain reaction and sequencing platforms.

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