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Qiuli Liu and Margaret T.T. Wong-Riley Postnatal development of brain-derived neurotrophic factor (BDNF) and tyrosine protein kinase B (TrkB) receptor immunoreactivity in multiple brain stem respiratory-related nuclei of the rat Journal of Comparative Neurology 521

Version of Record online: 22 NOV 2012 | DOI: 10.1002/cne.23164

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A critical period of postnatal respiratory development exists, during which heightened inhibition and suppressed excitation accompany a weak response to hypoxia. We hypothesized that the imbalance stemmed from a reduced expression of brain-derived neurotrophic factor (BDNF) and its tyrosine protein kinase B (TrkB) receptors, which normally potentiate excitation and attenuate inhibition. Our findings confirmed our hypothesis that the expressions of BDNF and TrkB were significantly reduced in seven respiratory-related nuclei (but not in a nonrespiratory nucleus) during the critical period.

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