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David H. Root, Sisi Ma, David J. Barker, Laura Megehee, Brendan M. Striano, Carla M. Ralston, Anthony T. Fabbricatore and Mark O. West Differential roles of ventral pallidum subregions during cocaine self-administration behaviors Journal of Comparative Neurology 521

Article first published online: 17 DEC 2012 | DOI: 10.1002/cne.23191

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Dorsolateral ventral pallidum (VPdl) neurons exhibit greater changes in firing rate (FR) during cocaine-seeking responses than ventromedial ventral pallidum (VPvm) neurons. y Axis is cumulative proportion of neurons; x axis is absolute change in FR during response. Red and black lines indicate cumulative proportions for VPdl and VPvm neurons, respectively. Median values are circle (VPdl) and square (VPvm). Accumbens shell and core project to VPvm and VPdl, respectively, suggesting that the core-VPdl subcircuit is especially critical for drug-seeking behavior. **P < 0.01.

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