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Richard C. Krolewski, Adam Packard and James E. Schwob Global expression profiling of globose basal cells and neurogenic progression within the olfactory epithelium Journal of Comparative Neurology 521

Version of Record online: 22 JAN 2013 | DOI: 10.1002/cne.23204

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Three lines of eGFP-expressing mice were used for FACS isolating sustentacular cells, Sox2-expressing globose basal cells (GBCs), Neurog1-expressing GBCs, and OMP-expressing neurons from adult olfactory epithelium. Distinct, but overlapping gene expression profiles characterized each set of isolates. Among the differentially expressed genes were members of the coREST complex, a histone modifier. The data illuminate and help explicate the transitions as cells progress along the neurogenic path from stem cell to fully mature olfactory sensory neuron.

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