Jason J. Ivanusic, Rhiannon J. Wood and James A. Brock Sensory and sympathetic innervation of the mouse and guinea pig corneal epithelium Journal of Comparative Neurology 521
In both mouse and guinea pig corneal epithelium, calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve terminals, which are likely to be nociceptive, are predominantly simple. In contrast, transient receptor potential subfamily M member 8 channel immunoreactive (TRPM8-IR) nerve terminals, which are likely to be cold receptive, are highly branched and complex. The findings suggest that corneal sensory nerve terminals with different modalities can be defined by their neurochemistry and morphology.
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