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Lynn D. Selemon, Can Ceritoglu, J. Tilak Ratnanather, Lei Wang, Michael P. Harms, Kristina Aldridge, Anita Begović, John G. Csernansky, Michael I. Miller and Pasko Rakic Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestation Journal of Comparative Neurology 521

Version of Record online: 29 JAN 2013 | DOI: 10.1002/cne.23217

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Environmental insult to the developing brain has been linked to neuropsychiatric conditions, including mental retardation, fetal alcohol syndrome, and schizophrenia. Cortical pathology in adult macaques was examined following irradiation at two prenatal ages. Early gestational irradiation resulted in modest decreases in cortical surface area and volume. Midgestational exposure produced more pronounced size reduction, including cortical thinning, and a cell-sparse stratum (arrows) marking the position of irradiation-killed neurons. Gestational age is a critical determinant of cortical pathology consequent to environmental insult.

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