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Jeffrey Helgager, Gumei Liu and James O. McNamara The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis Journal of Comparative Neurology 521

Version of Record online: 17 DEC 2012 | DOI: 10.1002/cne.23225

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Signaling through the neurotrophin receptor, tropomyosin-related kinase B (TrkB), is thought to be critical for limbic epileptogenesis, the process by which a normal brain becomes epileptic. This study elucidates the locales of activated TrkB within the hippocampus in a mouse model of epileptogenesis, revealing its presence at cellular and synaptic locales within mossy fibers and CA1 pyramidal cells. Knowledge of where TrkB undergoes activation is necessary to understand its functional consequences, and may facilitate an understanding of the cellular mechanisms of epileptogenesis.

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