Clement C. Cheung, Deborah M. Kurrasch, Jenna K. Liang and Holly A. Ingraham Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH Journal of Comparative Neurology 521
Ventromedial hypothalamic nucleus (VMH) projections were genetically traced in the developing mouse by using a knock-in approach (Sf-1TauGFP) or by using an SF-1 Cre-driver (Z/EGSf-1:Cre) to express GFP. VMH projections begin at the onset of neurogenesis and closely resemble pathways previously mapped in the adult rat. Although neurons in the VMHVL are derived from the SF-1 lineage as shown in the Z/EGSf-1:Cre reporter, they adopt a distinct, SF-1-negative cell fate after midgestation, as shown in the Sf-1TauGFP reporter.
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