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Laura B. Buckman, Misty M. Thompson, Heidi N. Moreno and Kate L.J. Ellacott Regional astrogliosis in the mouse hypothalamus in response to obesity Journal of Comparative Neurology 521

Article first published online: 20 FEB 2013 | DOI: 10.1002/cne.23233

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In response to CNS challenge astrocytes undergo a process of hypertrophy and hyperplasia called reactive astrogliosis. We examined the differential distribution of the astrocyte marker glial-fibrillary acidic protein (GFAP) in the brains of diet-induced or genetically obese mice compared with lean controls. Areas that showed the highest differential GFAP-immunoreactivity between lean and obese animals include the medial preoptic, paraventricular and dorsomedial nuclei. The consequences of obesity-associated astrogliosis are undetermined but likely have wide-ranging implications for metabolism and other neuroendocrine axes.

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