Katherine J. Kopeikina, Manuela Polydoro, Hwan-Ching Tai, Erich Yaeger, George A. Carlson, Rose Pitstick, Bradley T. Hyman and Tara L. Spires-Jones Synaptic alterations in the rTg4510 mouse model of tauopathy Journal of Comparative Neurology 521
In Alzheimer Disease (AD), the role of tau in synapse loss remains largely undetermined. Here we test the hypothesis that human mutant tau over-expression in a mouse model will lead to age-dependent synaptic loss and dysfunction. Array tomography and two methods of quantification demonstrate preservation of overall synapse density in the neuropil, while multi-photon in vivo imaging shows close to 30% loss of apical dendritic spines. Biochemical analyses of remaining synapses suggest loss of synaptic components likely indicating concomitant dysfunction.
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