E-mail

E-mail a Wiley Online Library Link

Brian A. Couch, Meghan E. Kerrisk, Adam C. Kaufman, Haakon B. Nygaard, Stephen M. Strittmatter and Anthony J. Koleske Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice Journal of Comparative Neurology 521

Version of Record online: 20 FEB 2013 | DOI: 10.1002/cne.23239

Thumbnail image of graphical abstract

Transgenic mice expressing mutant forms of amyloid-β precursor protein (AβPP) and presenilin-1 (PS1) recapitulate several aspects of Alzheimer's disease (AD). Here we show using Thioflavin-S staining that outcrossed AβPP/PS1 mice have lower hippocampal amyloid plaque burden than inbred C57BL/6 AβPP/PS1 mice at 12 months. Furthermore, outcrossed AβPP/PS1 mice have delayed memory-based behavioral impairments and AβPP processing. These data suggest that genetic elements present in certain mouse strains can significantly delay the onset of AD-like pathology and behavior.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH