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Brian A. Couch, Meghan E. Kerrisk, Adam C. Kaufman, Haakon B. Nygaard, Stephen M. Strittmatter and Anthony J. Koleske Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice Journal of Comparative Neurology 521

Version of Record online: 20 FEB 2013 | DOI: 10.1002/cne.23239

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Transgenic mice expressing mutant forms of amyloid-β precursor protein (AβPP) and presenilin-1 (PS1) recapitulate several aspects of Alzheimer's disease (AD). Here we show using Thioflavin-S staining that outcrossed AβPP/PS1 mice have lower hippocampal amyloid plaque burden than inbred C57BL/6 AβPP/PS1 mice at 12 months. Furthermore, outcrossed AβPP/PS1 mice have delayed memory-based behavioral impairments and AβPP processing. These data suggest that genetic elements present in certain mouse strains can significantly delay the onset of AD-like pathology and behavior.

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