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Hugh D. Simpson, Elizabeth M. Kita, Ethan K. Scott and Geoffrey J. Goodhill A quantitative analysis of branching, growth cone turning, and directed growth in zebrafish retinotectal axon guidance Journal of Comparative Neurology 521

Version of Record online: 20 FEB 2013 | DOI: 10.1002/cne.23248

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When imaging zebrafish retinotectal axon targeting on the tectum, we found growth cones moving with mostly straight trajectories without turning. Instead, axons navigated through dynamic branching, with a bias for branches directed towards their target region. These results suggest that selective branching during initial pathfinding may be a ubiquitous feature of guidance during retinotectal / retinocollicular map formation across a range of species, not just birds and mammals.

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