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Yao Liu, Jerome A. Staal, Alison J. Canty, Matthew T. K. Kirkcaldie, Anna E. King, Olivier Bibari, Stan T. Mitew, Tracey C. Dickson and James C. Vickers Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice Journal of Comparative Neurology 521

Article first published online: 4 APR 2013 | DOI: 10.1002/cne.23261

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Neurofilament light (NFL) is an obligate subunit for neurofilament triplet intermediate filaments. We examined the effect of NFL knockout on the expression of cytoskeletal proteins in the cortex at 4 days, 5 months, and 12 months postnatally. Deleting NFL alters the expression of intermediate filament proteins, including α-internexin, and disrupts neurofilament assembly and transport, causing intracellular aggregation but no gross structural changes in cytoarchitecture. In addition, changes in expression of other cytoskeletal proteins may compensate for altered neurofilament expression.

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