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Julie A. Markham, Sylvina E. Mullins and James I. Koenig Periadolescent maturation of the prefrontal cortex is sex-specific and is disrupted by prenatal stress Journal of Comparative Neurology 521

Article first published online: 4 APR 2013 | DOI: 10.1002/cne.23262

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Gestational stress is associated with increased risk for both cognitive deficits and schizophrenia, a psychiatric illness that emerges during adolescence and is more common among men. We find that maturation of prefrontal neurons follows a sex-specific pattern during normal development and that this pattern is disrupted during adolescence in prenatally stressed males. These findings may be relevant to both the development of normal sex differences in cognition and differential male–female vulnerability to mental illness.

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