Melissa J.S. Chee, Pavlos Pissios and Eleftheria Maratos-Flier Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus Journal of Comparative Neurology 521
Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide that acts on MCH receptors 1 (MCHR1) in rodents. This study uses the Mchr1-cre/tdTomato mouse to readily identify MCHR1-expressing neurons by red fluorescence. We found that MCHR1 is expressed in different cell types throughout the hypothalamus. Thus we provide a neuroanatomical basis for MCH to regulate neuroendocrine and autonomic functions, including energy balance and appetite.
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