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Guibao Gu, Barbara Roland, Kevin Tomaselli, Carrie S. Dolman, Carolyn Lowe and Joseph S. Heilig Glucagon-like peptide-1 in the rat brain: Distribution of expression and functional implication Journal of Comparative Neurology 521

Version of Record online: 19 APR 2013 | DOI: 10.1002/cne.23282

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Glucagon-like-peptide 1 (GLP-1) is not only secreted by gut endocrine cells but also expressed in a small number of neurons in the caudal brainstem. These neurons send massive outputs to other areas of the brain, particularly forebrain, that are known to be involved in metabolic homeostasis. Peripheral administration of GLP-1 receptor agonist does not appear to activate GLP-1-containing neurons directly, but activates areas in the forebrain where abundant GLP-1-containing terminals are found, suggesting central GLP-1-mediated activity is independent of peripheral GLP-1.

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