Corinna Darian-Smith, Alayna Lilak and Christina Alarcón Corticospinal sprouting occurs selectively following dorsal rhizotomy in the macaque monkey Journal of Comparative Neurology 521
The corticospinal tract in the macaque and human originates from at least nine separate cortical regions, and is the major descending pathway mediating volitional hand movements. Here we compared primary motor and somatosensory corticospinal subcomponents in the recovery process several months following a unilateral cervical dorsal rhizotomy in macaques. Our findings show a very different response from each cortical region, indicating that each plays a very different role post injury. Our findings also indicate that the corticospinal tract response to spinal cord injury is considerably more complex than is generally recognized.
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