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Dale F. Sharrad, Wei-Ping Gai and Simon J.H. Brookes Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum Journal of Comparative Neurology 521

Version of Record online: 4 JUN 2013 | DOI: 10.1002/cne.23296

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Mishandling of α-synuclein contributes to formation of Lewy bodies and Lewy neurites in Parkinson's disease. Here we show that the synaptic chaperones α-synuclein and cysteine string protein-α and the synaptic vesicle proteins synaptophysin, synaptotagmin-1, and synaptobrevin-2 are selectively coexpressed in cholinergic axons, marked by vesicular acetylcholine transporter, in the enteric nervous system of the guinea pig ileum. We speculate that the neurotransmitter-release mechanism utilized by cholinergic neurons in the gut may predispose them to degeneration in Parkinson's disease.

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