E-mail

E-mail a Wiley Online Library Link

Dale F. Sharrad, Wei-Ping Gai and Simon J.H. Brookes Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum Journal of Comparative Neurology 521

Article first published online: 4 JUN 2013 | DOI: 10.1002/cne.23296

Thumbnail image of graphical abstract

Mishandling of α-synuclein contributes to formation of Lewy bodies and Lewy neurites in Parkinson's disease. Here we show that the synaptic chaperones α-synuclein and cysteine string protein-α and the synaptic vesicle proteins synaptophysin, synaptotagmin-1, and synaptobrevin-2 are selectively coexpressed in cholinergic axons, marked by vesicular acetylcholine transporter, in the enteric nervous system of the guinea pig ileum. We speculate that the neurotransmitter-release mechanism utilized by cholinergic neurons in the gut may predispose them to degeneration in Parkinson's disease.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH