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Sarah E. Crowe and Graham C.R. Ellis-Davies In vivo characterization of a bigenic fluorescent mouse model of Alzheimer's disease with neurodegeneration Journal of Comparative Neurology 521

Version of Record online: 19 APR 2013 | DOI: 10.1002/cne.23306

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We have used longitudinal in vivo two-photon microscopy to study a new bigenic mouse model of Alzheimer's disease (5xFAD-YFP) that exhibits massive loss of fluorescently labeled layer 5 pyramidal neurons. Imaging of this transgenic mouse enabled the study of spine stability 500-600 μm below the pia mater, progressive atrophy of axons, appearance and growth of amyloid plaques, and eventual loss of neocortical pyramidal neurons.

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