Jacqueline Chua, Lisa Nivison-Smith, Erica L. Fletcher, Stuart Trenholm, Gautam B. Awatramani and Michael Kalloniatis Early remodeling of müller cells in the rd/rd mouse model of retinal dystrophy Journal of Comparative Neurology 521
In the rd/rd mouse, Müller cell processes are reduced in the outer retina during early degeneration but increase after total photoreceptor loss. Conversely, GFAP expression increases at early stages then decreases at older ages. Müller cell electrophysiology remains normal during early degeneration. Thus, rd/rd gliosis has an initial conservative response followed by active remodeling.
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