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Daniel Kueh, Jolene Appiah and John Jellies Maturation of peptide-positive synaptic arbors in the medicinal leech requires rhythmic target activity Journal of Comparative Neurology 521

Article first published online: 19 JUN 2013 | DOI: 10.1002/cne.23319

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The formation of peptide-containing presynaptic varicosities in a motor neuron depends on rhythmic activity of the target and motor neuron. Disruption of rhythmic central pattern generator (CPG) drive during early development results in a pronounced deficit of motor synapses.

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