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Sravan Mandadi, Peter Hong, Michelle A. Tran, Joao M. Bráz, Pina Colarusso, Allan I. Basbaum and Patrick J. Whelan Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord Journal of Comparative Neurology 521

Version of Record online: 19 JUN 2013 | DOI: 10.1002/cne.23321

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It has been recognized for many years than long-range afferents travel multiple segments within the spinal cord but their function has been elusive. Here we present anatomical and electrophysiological evidence that molecularly defined TRPV1 nociceptive afferents that project multiple segments within the lumbosacral spinal cord can functionally affect rhythmic motor behaviors.

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