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Jin-Dong Ding, Mary B. Kennedy and Richard J. Weinberg Subcellular organization of camkii in rat hippocampal pyramidal neurons Journal of Comparative Neurology 521

Article first published online: 23 AUG 2013 | DOI: 10.1002/cne.23372

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Using quantitative postembedding immunogold electron microscopy, we find that near the middle of the synaptic apposition, CaMKII concentrates ∼40 nm away from the plasma membrane (at the cytoplasmic fringe of the postsynaptic density), whereas at the edge of the synapse it concentrates much closer to the membrane. These different pools of CaMKII may play distinct roles in synaptic plasticity.

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