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A.V. Kuznetsov A model of axonal transport drug delivery: effects of diffusivity International Journal for Numerical Methods in Biomedical Engineering 28

Version of Record online: 28 FEB 2012 | DOI: 10.1002/cnm.2469

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The effects of diffusivity on retrograde dynein-driven transport of pharmaceutical agent complexes (PACs) in axons are investigated. An analytically tractable model of targeted axonal transport drug delivery is developed. The effects of diffusivity and the kinetic rates describing PAC transition between the dynein-driven and accumulated states on transport of PACs toward the neuron soma are investigated.

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