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E. Boileau, R. L. T. Bevan, I. Sazonov, M. I. Rees and P. Nithiarasu Flow-induced ATP release in patient-specific arterial geometries – a comparative study of computational models International Journal for Numerical Methods in Biomedical Engineering 29

Version of Record online: 25 JUL 2013 | DOI: 10.1002/cnm.2581

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Distributed models for adenosine-5’-triphosphate (ATP) release aimed at describing the catalytic reactions at the endothelium are reviewed and critically examined. A general modelling framework is presented. Simulations performed on image-based patient-specific geometries reveal that existing paradigms may not account for the conditions encountered in vivo and may therefore not be adequate to model the kinetics of ATP at the endothelium.

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