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S. Scheiner, P. Pivonka, D. W. Smith, C. R. Dunstan and C. Hellmich Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab International Journal for Numerical Methods in Biomedical Engineering 30

Version of Record online: 30 AUG 2013 | DOI: 10.1002/cnm.2584

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A pharmacokinetics model of the anti-catabolic drug denosumab is combined with an integrated systems biology/multiscale bone mechanics model of bone remodeling for the purpose of studying the disease progress of postmenopausal osteoporosis, with and without taking into account drug intervention by means of denosumab. The thereby obtained model predictions agree well with corresponding biomarker measurements. The results presented here also motivate to invest in explicit modeling of the secondary bone mineralization process and its linkage to RANKL and osteocytic actions.

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