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Masanori Nakamura, Sadao Bessho and Shigeo Wada Analysis of Red Blood Cell Deformation under Fast Shear Flow for Better Estimation of Hemolysis International Journal for Numerical Methods in Biomedical Engineering 30

Version of Record online: 15 AUG 2013 | DOI: 10.1002/cnm.2587

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The study is aimed to determine whether the extent of red blood cell (RBC) deformation is correlated with the shear stress used as a hemolysis index. The RBC deformation was assessed by the maximum first principal strain. Although the results were consistent under steady Couette flow, this was not the case under unsteady Couette flow or stenosed flow. These results suggest that there is a limitation in accurately estimating the mechanical damage of RBCs solely from a macroscopic flow field.

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